Not really certain what you mean by that. Assuming that you’re using a Linux distribution, you can map multiple drives to that installation. Really it depends on what you want to do and how you do it. There are many, many options. If you are not familiar with a unix-based environment, I would advise that you start there and figure out later what distro you want to use and how you want to use it.
thatºs my objective. But I’m just not sure how to organize OS and the rest of the data. Or if I just use an SSD, or just an NVMe drive…
Not really certain what you mean by that. Assuming that you’re using a Linux distribution, you can map multiple drives to that installation. Really it depends on what you want to do and how you do it. There are many, many options. If you are not familiar with a unix-based environment, I would advise that you start there and figure out later what distro you want to use and how you want to use it.