• wjrii@lemmy.world
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    18 hours ago

    For the record, mixing two painkillers without consulting a doctor is also usually a bad idea but way fucking less of a bad idea than taking 13000mg of tylenol in a day.

    Basically, if something hurts so much that you might take enough paracetamol/acetaminophen to fuck with your liver then you yes, you should be under a doctor’s care. That said, between my wife and me, we’ve had three or four doctors over the years all be very chill with the idea of alternating Tylenol and Ibuprofen after surgery or the like. I guess they work on such different chemical pathways that they don’t have much interaction potential, and keeping under the daily dose of Tylenol in particular is incredibly important, as we’ve seen in this thread.

    • Ledericas@lemm.ee
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      8 hours ago

      tyelonol works on the liver, the others like ibuprofen, naproxen,etc works by inhibiting the cox1 and 2 enzymes. of courses take 2 much of the inhibitors is very similar to aspirin, it can prevent clotting(which in itself is a therapeuthic uses for clotting disorders)

    • SolOrion@sh.itjust.works
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      10 hours ago

      yes, you should be under a doctor’s care.

      That’s not always an option, unfortunately, but it’s definitely accurate.

    • peoplebeproblems@midwest.social
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      18 hours ago

      They act on different systems, yes, but this is more about the metabolism of each.

      Non-steroidal-anti-inflamatorirs can cause damage to your stomach and kidneys.

      Acetaminophen/Paracetol metabolizes in the liver a similar way alcohol does, and like alcohol has a maximum rate of clearing the toxin.