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You can reduce their effectiveness though.
Do you have a source for that?
Still, the vast majority of people taking NSAIDs in the recommended doses who have appropriate monitoring (such as the occasional blood test) have no major problems with them.
My doctor, but there’s a bunch of studies where they injected rats too.
Not in humans, but an indicator anyhow: https://pmc.ncbi.nlm.nih.gov/articles/PMC4341275/
